Metamaterials for Enhanced Polarization Conversion in Plasmonic Excitation

Surface plasmons efficient excitation is typically expected to be strongly constrained to transverse magnetic (TM) polarized incidence, as demonstrated so far, due to its intrinsic TM polarization. We report a designer plasmonic metamaterial that is engineered in a deep subwavelength scale in visible optical frequencies to overcome this fundamental limitation, and allows transverse electric (TE) polarized incidence to be strongly coupled to surface plasmons. The experimental verification, which is consistent with the analytical and numerical models, demonstrates this enhanced TE-to-plasmon coupling with efficiency close to 100%, which is far from what is possible through naturally available materials. This discovery will help to efficiently utilize the energy fallen into TE polarization and drastically increase overall excitation efficiency of future plasmonic devices

Self alignment and instability of waveguides induced by optical forces

We introduce a new fundamental property of waveguides induced by the forces of the guided light, namely, the ability to self align or be in instability. A nanoscale waveguide broken by an offset and a gap may tend to self align to form a continuous waveguide. Conversely, depending on the geometry and light polarization, the two parts of the waveguide may be deflected away from each other, thus being in an unstable state. These effects are unique as they rely on the presence of both the guided mode and the scattered light. Strong self alignment forces may be facilitated by near field interaction with polarization surface charges

The non-coding transcriptome as a dynamic regulator of cancer metastasis.

Since the discovery of microRNAs, non-coding RNAs (NC-RNAs) have increasingly attracted the attention of cancer investigators. Two classes of NC-RNAs are emerging as putative metastasis-related genes: long non-coding RNAs (lncRNAs) and small nucleolar RNAs (snoRNAs). LncRNAs orchestrate metastatic progression through several mechanisms, including the interaction with epigenetic effectors, splicing control and generation of microRNA-like molecules. In contrast, snoRNAs have been long considered "housekeeping" genes with no relevant function in cancer. However, recent evidence challenges this assumption, indicating that some snoRNAs are deregulated in cancer cells and may play a specific role in metastasis. Interestingly, snoRNAs and lncRNAs share several mechanisms of action, and might synergize with protein-coding genes to generate a specific cellular phenotype. This evidence suggests that the current paradigm of metastatic progression is incomplete. We propose that NC-RNAs are organized in complex interactive networks which orchestrate cellular phenotypic plasticity. Since plasticity is critical for cancer cell metastasis, we suggest that a molecular interactome composed by both NC-RNAs and proteins orchestrates cancer metastasis. Interestingly, expression of lncRNAs and snoRNAs can be detected in biological fluids, making them potentially useful biomarkers. NC-RNA expression profiles in human neoplasms have been associated with patients' prognosis. SnoRNA and lncRNA silencing in pre-clinical models leads to cancer cell death and/or metastasis prevention, suggesting they can be investigated as novel therapeutic targets. Based on the literature to date, we critically discuss how the NC-RNA interactome can be explored and manipulated to generate more effective diagnostic, prognostic, and therapeutic strategies for metastatic neoplasms

Thermal scaling laws of the optical Bragg acceleration structure

The temperature distribution and heat flow in the planar optical Bragg acceleration structure, fed by a train of high-power laser pulses, are analyzed. Dynamic analysis of a high-repetition rate train of pulses indicates that the stationary solution is an excellent approximation for the regime of interest. Analytic expressions for the temperature and heat distributions across the acceleration structure are developed. Assuming an accelerating gradient of 1  GV/m and a loss factor similar to that existing in communication optical fibers 1   dB/km (tan⁡δ∼10^{-11}), the temperature increase is less than 1 K and the heat flow is of the order of 1   W/cm^{2}, which is 3 orders of magnitude lower than the known technological limit for heat dissipation. Obviously, using materials with a significantly higher loss tangent may lead to unacceptable temperatures and temperature gradients as well as confinement difficulties and phase mismatch

Functional Plasticity of Odor Representations during Motherhood

Summary: Motherhood is accompanied by new behaviors aimed at ensuring the wellbeing of the offspring. Olfaction plays a key role in guiding maternal behaviors during this transition. We studied functional changes in the main olfactory bulb (OB) of mothers in mice. Using in vivo two-photon calcium imaging, we studied the sensory representation of odors by mitral cells (MCs). We show that MC responses to monomolecular odors become sparser and weaker in mothers. In contrast, responses to biologically relevant odors are spared from sparsening or strengthen. MC responses to mixtures and to a range of concentrations suggest that these differences between odor responses cannot be accounted for by mixture suppressive effects or gain control mechanisms. In vitro whole-cell recordings show an increase in inhibitory synaptic drive onto MCs. The increase of inhibitory tone may contribute to the general decrease in responsiveness and concomitant enhanced representation of specific odors. : Motherhood is associated with changes in neural circuits that affect how the mother senses her surroundings. Vinograd et al. show that the olfactory bulb is a locus of plasticity. Output neurons of the bulb have elevated inhibition, and odor coding of natural odors is improved. Keywords: olfaction, plasticity, mitral cells, motherhood, two-photon, calcium imaging, inhibitio

Cholesterol Catabolism by Mycobacterium tuberculosis Requires Transcriptional and Metabolic Adaptations

To understand the adaptation of Mycobacterium tuberculosis to the intracellular environment, we used comprehensive metabolite profiling to identify the biochemical pathways utilized during growth on cholesterol, a critical carbon source during chronic infection. Metabolic alterations observed during cholesterol catabolism centered on propionyl-CoA and pyruvate pools. Consequently, growth on this substrate required the transcriptional induction of the propionyl-CoA-assimilating methylcitrate cycle (MCC) enzymes, via the Rv1129c regulatory protein. We show that both Rv1129c and the MCC enzymes are required for intracellular growth in macrophages and that the growth defect of MCC mutants is largely attributable to the degradation of host-derived cholesterol. Together, these observations define a coordinated transcriptional and metabolic adaptation that is required for scavenging carbon during intracellular growth